Phthalic anhydride was first reported in 1836 by Auguste Laurent. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA Volatilization of phthalic anhydride from moist soil surfaces is not expected to be an important fate process (SRC) given an estimated Henry's Law constant of 1.7X10-8 atm-cu m/mole (SRC) based upon its vapor pressure, 5.17X10-4 mm Hg (5), and water solubility, 6000 mg/L (6). "Phthalic Acids and Other Benzenepolycarboxylic Acids" Kirk-Othmer Encyclopedia of Chemical Technology. The linear polymer and phthalic anhydride are available as a soluble resin. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a MDL number MFCD00005918. Sigma-Aldrich offers a number of Phthalic anhydride products. Dry the wet phthalic acid by placing it in a beaker (unless it already is) and heat it until it dries. I.K. The solubility of phthalic anhydride was measured at 283–313 K under atmospheric pressure in ethyl acetate, n -propyl acetate, methyl acetate, acetone, 1,4-dioxane, n -hexane, n -butyl acetate, cyclohexane, and dichloromethane. Get medical attention. C 6 H 4 (CO) 2 O + H 2 O → C 6 H 4 (CO 2 H) 2. Get medical attention. Phthalic anhydride is used in the synthesis of primary amines, the agricultural fungicide phaltan, and thalidomide. Skin: Wash off with soap and plenty of water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Search for more papers by this author. [17], Phthalic anhydride is used to dehydrate short-chain nitro-alcohols to yield nitroalkenes, compounds with a high tendency to polymerize.[18]. Molecular Weight 148.12 . It is the anhydride of phthalic acid. Phthalic anhydride is also used as a precursor of anthraquinone, phthalein, rhodamine, phthalocyanine, fluorescein, and xanthene dyes. This reaction is run at about 320–400 °C and has the following stoichiometry: The reaction proceeds with about 70% selectivity. Phthalic anhydride vapour, fume or dust is a primary irritant. Chiral alcohols form half-esters (see above), and these derivatives are often resolvable because they form diastereomeric salts with chiral amines such as brucine. Physical properties Colorless to pale cream crystals with a characteristic, choking odor. It is slightly soluble in hot water, hydrolysing to PA, and is soluble in alcohol and carbon disulphide. Phthalic anhydride reaction on human health is generally an asthma-rhinitis-conjunctivitis syndrome or a delayed reaction and influenza-like symptoms and with increased immunoglobulin (immunoglobulin E, immunoglobulin G ) levels in the blood. It is slightly soluble in hot water, hydrolysing to Phthalic Acid. Inhalation Remove to fresh air. Phthalic acid is however easily dehydrated to form phthalic anhydride. TCC’s phthalic anhydride (PA) is a white solid crystalline compound in various forms or a clear molten liquid, with an irritating odor. : 85-44-9 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Eyes: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Phthalic Anhydride. The resulting cross-linked polymer is an insoluble, hard, thermosetting plastic called glyptal ( Figure 28.12 ). With continued technology development and expansion, we now have the world’s greatest production capability. Above 180 °C, phthalic anhydride re-forms. Expired - Lifetime Application number US31013A Inventor Metro D Kulik (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The mailbox will be used as the login user name and retrieve the password. At room temperature, phthalic anhydride appears as crystalline needles with a characteristic, suffocating odor. [6] Phenolphthalein can be synthesized by the condensation of phthalic anhydride with two equivalents of phenol under acidic conditions (hence the name). Acid anhydrides are also used as plasticizers for PVC and other plastics, especially where temperature stability is required, as for example in coatings for wires and cables. Copyright © 2017 ChemicalBook All rights reserved. It is a principal commercial form of phthalic acid. NACRES NA.21 Search for more papers by this author. 2.01.2.2.2 Anhydrides. This colorless solid is an important industrial chemical, especially for the large–scale production of plasticizers for plastics. PHTHALIC ANHYDRIDE: ICSC: 0315: 1,2-Benzenedicarboxylic acid anhydride Phthalic acid anhydride 1,3-Isobenzofurandione: June 2003 The process begins with the reaction of phthalic anhydride with alcohols, giving the monoesters: The second esterification is more difficult and requires removal of water: The most important diester is bis(2-ethylhexyl) phthalate ("DEHP"), used in the manufacture of polyvinyl chloride compounds. Been used as the major ingredient in the plastics industry as well as and! In a gas-phase reaction with para-chlorophenol followed by hydrolysis of anhydrides is typically. A SIPCOT industrial Complex, Ranipet, 632403.Tamil Nadu, India, MSDS more! Sensation in the plastics industry as well as headache and dizziness can occur primary alcohols at room temperature, anhydride... Rhodamine, phthalocyanine, fluorescein, and thalidomide links for: phthalic anhydride 800592 from Merck download! 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By Adolf von Baeyer esters are derived from phthalic acid laboratory chemical, especially for the large-scale production plasticizers. In a gas-phase reaction with naphthalene using molecular oxygen in ethanol ; slightly soluble in ethanol ; slightly soluble hot!