To obtain detailed insight into this trajectory, it is essential to capture all the stages with single-cell accuracy. Read the new partnership agreement between Pontiac School District and the state including exhibits of data on the schools achievement gaps. Jobs; Jobs Tips; 11 Recession-Proof Jobs; How to Get a Job; The Perfect Resume Looks Like This; How to Write A Cover Letter; 9 Attention-Grabbing Cover Letter Examples; New On Glassdoor; Best Cities for Jobs 2020; Company Reviews . Other Annotations. 3584 CT Utrecht Anna Kicheva IST Austria Verified email at ist.ac.at. We are employing scDam&T to obtain a better understanding of the epigenetic mechanisms underlying lineage decisions in early embryogenesis, to identify the epigenetic trajectories of single cells that acquire malignant identities in tumorigenesis and to obtain insight into the role of chromatin in DNA double-strand repair. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. Spatiotemporal regulation of genomic function; Hubrecht Institute. 23. Jop, now Group Leader at … Molecular biologist dr. Jop Kind (1978) joined the Van Steensel lab as a postdoc after a highly successful PhD at the EMBL. That way, we hope to better understand the relationship between epigenetics and the emergence of new cell types”, says Kind. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Jop Kind, Group Leader at Hubrecht Institute and Oncode Investigator, will bring you up to speed with the basics of Single Cell Technology. Wednesday 22 July. Verified account Protected Tweets @; Suggested users He will zoom in on single-cell epigenomics and multi-omics. jop kind. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. We profiled these genome-lamina interactions in single cells to obtain better understanding in gene-regulation control in pre- and post-implantation embryos (Borsos et al., 2019, Nature) (Figure 2). Spatiotemporal regulation of genomic function; Hubrecht Institute. ); s.kefalopoulou@hubrecht.eu (S.K.) Institute of Molecular Biotechnology, Austrian academy of science. About. Knipscheer’s group will use the ERC grant to further research this pathway. In this conversation. “Our overarching goal is to further research current pathways and discover new ones in order to better understand how cells repair this type of DNA damage”, says Knipscheer. He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. The Kind group uses a combination of single-cell genomics and microscopy methods to study the role of chromatin and epigenetics in gene-regulation control, with a focus on early mouse embryonic development and tumorigenesis. Mechanisms underlying cell-fate choice in early embryogenesis The researchers in Kind’s group will use the ERC grant to further research when and how cells make these identity choices. The grant allows her to expand her group with 4 researchers for the duration of 5 years. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Visit Kind's page. Dive into the research topics where Jop Kind is active. Hubrecht Institute opens new laboratory building. Jop Kind leads a Developmental Epigenomics group at Hubrecht Institute, Netherlands. Jop Kind Group. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Uppsalalaan 8 Jop Kind lab. Reads . Puck Knipscheer Group. Year; Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Afterwards, Alexander van Oudenaarden, Mauro Muraro and Waleed Kholosy will also give talks and elaborate on some specific applications and usage of single cell technology. The Consolidator Grant is specifically awarded to researchers who have formed their own research group relatively recently and aim to further strengthen it further. Duplicate citations. His group is focused on understanding how spatial and temporal changes in genome architecture affect gene expression. The group focuses on a specific type of DNA damage called a DNA interstrand crosslink (ICL). Hubrecht Institute. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Cell division & chromosome segregation; Hubrecht Institute. EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. This method enables linking transcriptional variability to epigenetic heterogeneity. 12:35. Fingerprint. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. Jop Kind Group Jop Kind Oncode Investigator at Hubrecht Institute My Research. Ester Frische; Mariëlle Harlé; Yuva Oz; Jacqueline Staring; Peter Thijssen; More information will follow. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research . EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. The aim of the lab is to understand the principles governing cellular decision-making. Articles … Tumorigenesis involves the continuous selective adaptation of cells from healthy tissue, to adenoma, carcinoma and eventually metastasis. Uppsalalaan 8 About. PMID: 31118510 PMCID: PMC6546605 Currently, there are more than 70 PhD students at the Hubrecht Institute. Research output per year. Jop Kind, group leader at the Hubrecht Institute, has been awarded the John Kendrew award. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. That knowledge underlines the link between alcohol consumption and cancer. j.kind@hubrecht.eu. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to … A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. In addition, scDam&T allows determining cellular identity of cells in complex tissues -such as embryos or tumors- based on transcriptomics, in direct relation to their epigenetic regulatory landscapes (DamID). Jop Kind lab. Oncode Investigator at Hubrecht Institute My Research Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. More information. Cited by. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (Figure 3). Puck Knipscheer is group leader at the Hubrecht Institute and Oncode investigator. The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Verified email at hubrecht.eu. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. This "Cited by" count includes citations to the following articles in Scholar. Publications 23. 3584 CT Utrecht Save the date for our Annual Conference! KIT, Royal Tropical Institute. Hubrecht Institute. Contact. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. Friends raise €290.800,- for Hubrecht Institute. This type of DNA damage can have an endogenous cause, but it can also be caused by external influences, such as high dosages of chemotherapy in cancer. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. Articles Cited by. The ERC-starting grants are awarded to support up-and-coming research leaders who have recently established their own research team in Europe. PhD. In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. 2 day event 19 - 20 Apr. Best Cities for Jobs 2020 NEW! Scientists from the groups of Puck Knipscheer (Hubrecht Institute) and Ketan J. Patel (MRC Laboratory of Molecular Biology) studied the second line of … Additionally, they will investigate whether there are other, currently unknown pathways involved in repairing ICLs. Publications. By Jop Kind, Hubrecht Institute. Puck Knipscheer Group. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. Geert Kops Group. Jop, now Group Leader at … Jop Kind, Junior Group Leader at the Hubrecht Institute. Their combined citations are counted only for the first article. Furthermore, as we consider technology development a core business of the group, we are continuously exploring ways to obtain richer single-cell datasets. Sara is now working as a computational biologist in the lab of Jop Kind at the Hubrecht Institute (Netherlands). (Jop) Kind: Active at: The Netherlands Cancer Institute: Hubrecht Institute for Developmental Biology and Stem Cell Research: Email address: If you have any questions or problems regarding login, please contact narcis@dans.knaw.nl. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. 13:05. 2 day event 19 - 20 Apr. Since October 2014 he is Junior Group Leader at the Hubrecht Institute. 3,331. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. 3,331. 13:05. torres-padilla@helmholtz-muenchen.de. Seeing is sequencing: linking phenotypes and genotypes of heterogeneous cancer cells by high-throughput, microscopy-based single cell selection and functionally annotated single cell sequencing. Self-organization in embryology. We are particularly interested in understanding the role of epigenetics and spatial genome organization in this process. Bob Roberts 2020-04-16 23:48:49? About the Hubrecht Institute Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. Jop Kind. In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. Mechanisms underlying cell-fate choice in early embryogenesis A major interest in the group is how gene-expression control is achieved in early embryogenesis. Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Reads . See what employees say about what it's like to work at Hubrecht Institute. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. Miao-Ping Chien. Go to Website Navigation: Home; about narcis; login; Nederlands; contact. Projects 1. We employ our single-cell genomic methods to study cellular trajectories on route towards malignant metastatic identities. Publications 23. Jobs. j.kind@hubrecht.eu. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Technology development Protein–DNA interactions are essential for establishing cell type–specific chromatin architecture and gene expression. Oncode, starting from a deeper understanding of the basics of cancer, works to come up with better treatments and improved diagnostics. That knowledge underlines the link between alcohol consumption and cancer. Wouter de Laat Group. PMID: 32350457 DOI: 10.1038/s41596-020-0314-8 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. The research group of Knipscheer researches DNA repair: how does our genetic material remain stable and how do we prevent the development of genetic diseases such as cancer? Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. These topic labels come from the works of this person. j.kind@hubrecht.eu. She and others previously discovered that the Fanconi anemia (FA) pathway plays a crucial role in repairing ICLs. Cell-fate decisions and the role of epigenetics in DNA double-strand repair Online event. 23. Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). Additionally, they study how new cell types arise in the early development of mouse embryos, in which epigenetics plays an important role. PHOTO: EMBL . Accurate repair of DNA damage is critical for the maintenance of genomic integrity. We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. Kim L de Luca 1 , Jop Kind 2 Affiliations 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. In particular, the group is interested in developing high-resolution single-cell techniques which can trace dynamic chromatin changes in living cells. To be announced. Jop Kind obtained his PhD from the Radboud University in Nijmegen for his work on dosage compensation in the lab of Asifa Akhtar at the EMBL Heidelberg. ERC-starting grant for Marvin Tanenbaum and Jop Kind. Credit: Jop Kind, copyright Hubrecht Institute. To be announced. The grant enables them to develop their own innovative line of research and set up their own research group. Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis. PhD. Accurate repair of DNA damage is critical for the maintenance of genomic integrity. Here For You During COVID-19 NEW! Jop Kind is group leader at the Hubrecht Institute and Oncode Investigator. Jop Kind. ERC-starting grant for Marvin Tanenbaum and Jop Kind Marvin Tanenbaum and Jop Kind, both group leader at the Hubrecht Institute, are awarded an ERC-starting grant. Cited by. j.kind@hubrecht.eu. Electronic address: j.kind@hubrecht.eu. Royal Netherlands Academy of Arts & Sciences (KNAW), Hubrecht Institute; 2015 2020. Kim L de Luca 1 , Jop Kind 2 ... 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Hubrecht Institute, NL. The European Research Council (ERC) awards grants to individual scientists of all nationalities and ages who perform groundbreaking research. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. hubrecht.eu. Cell division & chromosome segregation; Hubrecht Institute. martin 1st April 2015 News Read more Hiding in plain sight The grant was awarded to only 327 out of 2506 applicants. Sort by citations Sort by year Sort by title. A major interest in the group is how gene-expression control is achieved in early embryogenesis. The researchers want to know when and how cells in the early embryo ‘choose’ what type of cell they will become; whether they will for example become part of the skin or rather become part of the group of cells that forms the supporting embryonic tissue such as the placenta. Kind’s group previously developed advanced techniques with which they can study epigenetics in a single cell and match it with the cell’s choice of identity. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowl … The John Kendrew Young Scientist Award (JKA) was launched in 2007 as an initiative from the EMBL Pensioner’s Association to honour EMBL’s first Director General, Sir John Kendrew (1975-1982), and to support scientists in the early stages of their career. By Jop Kind, Hubrecht Institute. The Kind group researches gene regulation – how genes are turned on or off – and the influence of the packing of DNA, the epigenetics, on this mechanism. This is harmful because it prevents the DNA from replicating and thereby makes it impossible for cells to divide. Publications. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. Oncode is an independent institute dedicated to understanding cancer and translating research into practice. As a postdoctoral fellow in the lab of Bas van Steensel at the NKI, Jop developed novel techniques to visualize and profile single-cell spatial genome organization. An important contributor to the regulation of gene expression is the spatial positioning of genes within the 3-dimensional space of the nucleus. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Save the date for our Annual Conference! Read more | 5 November . Salaries, reviews, and more - all posted by employees working at Hubrecht Institute. Hubrecht Institute Summary: ... but instead attached to the ceiling at anchor points," says Jop Kind, group leader at the Hubrecht Institute. Read more | 18 November . 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, Kind’s work has paved the way for the development of powerful technologies to map chromatin, or balled-up DNA, in single cells, earning him this year’s John Kendrew Award. 2 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Together with her group, Knipscheer studies the repair pathways that cells use to correct ICLs. Hubrecht Institute launches new website! Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on the imaginative questions that led him to the prize . Jop is currently an associate professor at the Hubrecht Institute in Utrecht where his lab continues to develop new techniques to single-cell profile gene-regulation to obtain better insights into the mechanisms that govern cell fate choice in development and disease. Annual Scientific Meeting. Save the date! To this end we employ and continuously develop novel single-cell technologies to delineate these processes with high sensitivity and accuracy. In total the NWO has awarded 87 experienced researchers a Vidi grant worth 800,000 euros. Partnership Agreement for Pontiac School District - Free download as PDF File (.pdf) or read online for free. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. Jop Kind; Jurgen Marteijn; Titia Sixma; Organising Committee Oncode . Hubrecht Institute, Developmental Biology and Stem Cell Research | 6,134 followers on LinkedIn. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. The following articles are merged in Scholar. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research. Verified email at imba.oeaw.ac.at - Homepage. Tumor-cell trajectories in organoid and mouse models Job Corps is the largest Free residential education and job training program for young adults ages 16–24.. We connect you with the skills and education you need to get the career you want! Network. 3 day event 20 - 22 Jan. Masterclass: Artificial intelligence and deep learning in basic research and clinical practice in Oncology: In-depth sessions. Projects 1. Biomedical genomics; Hubrecht Institute. ‪Hubrecht Institute‬ - ‪Cited by 3,964‬ - ‪Single cell epigenomics‬ Citations per year. Annual Scientific Meeting. Award ceremony photo gallery. Modifications of the conceptus exposed key genes regulating these tissues co-development. Bob Roberts 2020-06-07 16:21:36 ? We profiled these genome-lamina interactions in single cells to obtain better understanding in gene-regulation control in pre- and post-implantation embryos (Borsos et al., 2019, Nature) (. Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. ). Jop Kind, Junior Group Leader at the Hubrecht Institute. 13:05. Maria-Elena Torres-Padilla is group leader and director of the Institute of Epigenetics and Stem Cells (IES), Helmholtz Center Munich and professor of Stem cell biology at the Ludwig-Maximilians University. The early mammalian conceptus (blastocyst) contains two supporting extraembryonic tissues - the trophectoderm and the primitive endoderm (PrE) - that encase and guide the epiblast (Epi) to eventually form the all body. Jop Kind Group. Jobs. Single cell epigenomics. 12:35. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The Netherlands; s.lochs@hubrecht.eu (S.J.A.L. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on … Silke J. Recently, however, her group also discovered a new pathway that is involved in ICL repair; they aim to further study this newly found DNA repair route. He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. Jop Kind Group Leader at Hubrecht Institute, Developmental Biology and Stem Cell Research Amsterdam en omgeving, Nederland Meer dan 500 connecties Biography. Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. Sort. Hubrecht Institute. Molecular mechanisms and regulation of DNA repair; Hubrecht Institute. Online event. Jop Kind. jop kind Hubrecht Institute Verified email at hubrecht.eu. Jop Kind, Junior Group Leader at the Hubrecht Institute. Jop Kind. Jop Kind The organization of DNA within the eukaryotic nucleus is important for cellular processes such as regulation of gene expression and repair of DNA damage. Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). Nicolas Rivron. About. https://lnkd.in/ekB-EJy #outsmartingcancer Hubrecht Institute, Developmental Biology and Stem Cell Research Knipscheer and Kind receive prestigious ERC Consolidator grant hubrecht.eu Overview; Fingerprint; Network; Research Output (8) Similar Profiles (28) If you made any changes in Pure these will be visible here soon. Jop Kind is group leader at the Hubrecht Institute and Oncode investigator. Save the date! … Get Funding: Convey the impact of your scientific vision. Tanenbaum: Single molecule observation and manipulation of gene expression dynamics … Erasmus University Medical Center/ UFO Biosciences, NL . We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. KIT, Royal Tropical Institute. We have developed scDam&T, a method to simultaneously capture protein-DNA interactions and transcriptomes in the same cell (Rooijers et al, 2019, Nature Biotechnology) (Figure 1). Network. Hubrecht Institute, NL. Oncode unites science, collaboration and valorization to create impact for patients. Jop Kind, group leader at the Hubrecht Institute, has been awarded a NWO Vidi-grant. To achieve this, we make use of organoid and mouse models that capture tumorigenesis all the way from the initiating stages towards metastasis. We are interested in how cells acquire new identities and traits in lineage specification events in mice and in cancer. Title. Additionally, they are planning to build so-called molecular time machines: by giving cells a mark in the earliest stages of embryonic development, the researchers can – once the cell has made its choice – trace the epigenetic status of the cells during the earlier stages of development. Miao-Ping Chien. Follow. Merged citations. 13:35. Read more | 11 November . Hubrecht Institute, NL. Past events. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. Wouter de Laat Group. Susanne Lens Group. Contact. An ICL occurs when the two strands of our DNA are connected unnaturally. Electronic address: j.kind@hubrecht.eu. cells Review Lamina Associated Domains and Gene Regulation in Development and Cancer Silke J. Geert Kops Group. ). Since October 2014 he is Junior Group Leader at the Hubrecht Institute. Login as Dr. J. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. Biomedical genomics; Salaries, reviews and more - all posted by employees working at Hubrecht Institute. The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. * Correspondence: j.kind@hubrecht.eu † These authors contributed equally to this work. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (.